Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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Review

  • Korean Journal of Biological Psychiatry
  • Volume 4(2); 1997
  • Article

Review

Korean Journal of Biological Psychiatry 1997;4(2):234-6. Published online: Feb, 1, 1997

Abstract PDF Full Text

Failure to Support Associations of Neurotrophin-3(NT-3) Gene Polymorphism in Korean Schizophrenic Patients

  • Yu-Sang Lee, MD1;Jin-Hee Han, MD2;Eun-Kee Chung, MD3;Byung-Hwan Yang, MD4;Hyeong-Seob Kim, MD1;Jung-Sik Lee, MD1;Yeon-Ho Joo, MD1; and Young-Gyu Chai, PhD5;
    1;Yong-In Psychiatric Research Institute, Yong-In Mental Hospital, Yongin, 2;Department of Psychiatry, Catholic University of Korea and St. Vincent Hospital, Suwon, 3;Seoul National Mental Hospital, Seoul, 4;Department of Psychiatry, College of Medicine and Mental Health Research Institute, Hanyang University, Seoul, 5;Department of Biochemistry and Molecular Biology, Hanyang University, Ansan, Korea
Abstract

Though initial report from Japan showed positive association of schizophrenia with dinucleotide repeat polymorphism in the NT-3 gene, subsequent studies showed mixed results. Therefore we conducted a replication study with Korean schizophrenics and matched controls who share similar ethnic background with Japanese population. The frequency of allele of dinucleotide repeat at 147 base pairs in the NT-3 gene was slightly increased, however, failed to reach statistical significance(χ2=1.884, df=1, p<0.170) between the two groups. These findings do not support an association of NT-3 gene polymorphism with schizophrenia in Korean sample.

Keywords Neurotrophin-3(NT-3);Dinucleotide repeat polymorphism;Association study;Schizophrenia.