Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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Review

  • Korean Journal of Biological Psychiatry
  • Volume 4(2); 1997
  • Article

Review

Korean Journal of Biological Psychiatry 1997;4(2):246-50. Published online: Feb, 1, 1997

Abstract PDF Full Text

Effect of MK-801 on the Prevention and Treatment of Tardive Dyskinesia

  • Jeong-Soo Seo, MD1;Young-Chul Chung, MD1;Keun-Young Park, MD3;Hong-Bai Eun, MD1;and Young-Hyun Kim, MD2;
    1;Department of Psychiatry, 2;Neurology, College of Medicine, Chonbuk National University, Chonju, 3;Department of Psychiatry, Baek Je General Hospital, Nonsan, Korea
Abstract

Tardive dyskinesia(TD) is a serious side effect of long-term treatment with neuroleptic medications. To investigate if glutamatergic hyperfunction is associated with TD, effect of MK-801 on the prevention and treatment of TD was studied using a rat model, ie, vacuous chewing movements(VCM). When comparing VCM scores of GroupI(haldol decanoate＋MK-801) with that of GroupII(haldol decanoate＋phosphate buffer saline), late measured VCM scores of former were significantly lower than that of latter, meaning that MK-801 is effective in the prevention of VCM. Furthermore, when MK-801(0.1mg/kg, 0.3mg/kg) is administered to VCM(＋) rats(VCM≥7/4min) of GroupII, VCM scores were significantly decreased, meaning that MK-801 is also effective in the treatment of VCM. From the above results, it is suggested that glutamatergic hyperfunction might be involved in the development of TD and MK-801 could be effective in the prevention and treatment of it.

Keywords MK-801;Tardive dyskinesia;Vacuous chewing movements(VCM).