Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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Review

  • Korean Journal of Biological Psychiatry
  • Volume 5(2); 1998
  • Article

Review

Korean Journal of Biological Psychiatry 1998;5(2):210-14. Published online: Feb, 1, 1998

Abstract PDF Full Text

An Association Study of COMT Gene Polymorphism with Korean Schizophrenics

  • En-Sook Song, PhD1;Byung-Hwan Yang, MD2;Kang-Kyu Park, MD3;Yu-Sang Lee, MD4;Eun-Soog An, MD4;Dong-Yul Oh, MD3;Jong-Won Kim, MD5;Ihn-Geun Choi, MD6;Gil-Sook Kim, MD3; and Young-Gyu Chai, PhD1;
    1;Department of Biochemistry and Molecular Biology, Hanyang University, Ansan, 2;Department of Neuropsychiatry, College of Medicine and The Mental Health Research Institute, Hanyang University, Seoul, 3;Seoul National Mental Hospital, Seoul, 4;Yong-In Mental Hospital, Yongin, Kyunggi-do, 5;Department of Psychiatry, College of Medicine, Ehwa University, Seoul, 6;Department of Neuropsychiatry, College of Medicine, Hallym University, Seoul, Korea
Abstract

An association study with Korean schizophrenic patients(N＝84) and normal controls(N＝87) was performed to find the relationship between catechol-Ο-methyltransferase(COMT) gene polymorphism and schizophrenia using polymerase chain reaction-restriction fragment length polymorphism. When we compared the allele and genotype frequencies of BglI COMT gene polymorphism in schizophrenics and normal controls, there was no significant difference between two groups. Our results do not support an association between the BglI polymorphism of COMT gene and schizophrenia.

Keywords Schizophrenia;Association;COMT;Polymorphism;Alleles.