Oct, 1, 2023

Vol.30 No.2, pp. 84-88

Current Issue Archives
Search
Advanced Search
Editorial Office

Review

  • Korean Journal of Biological Psychiatry
  • Volume 8(1); 2001
  • Article

Review

Korean Journal of Biological Psychiatry 2001;8(1):79-84. Published online: Jan, 1, 2001

Abstract PDF Full Text

Effect of Pretreatment of(-)-3-PPP on the Haloperidol-Induced Extracellular Dopamine Concentrations in the Nucleus Accumbens of Rats

  • Young-Chul Chung, MD1;Hong-Bae Eun, MD1;Ik-Keun Hwang, MD1; and Tae-Won Park, MD2;
    1;Department of Psychiatry, Institute for Medical Science and Research Institute of Clinical Medicine, Chonbuk National University, Medical School, Chonju, 2;Department of Psychiatry,Chonbuk National University Hospital, Chonju, Korea
Abstract

Objectives：To investigate the effects of(-)-3-PPP(0.5, 2, and 10mg/kg, s.c.) and haloperidol(0.1, 0.5, and 2mg/kg, s.c.) on the extracellular dopamine concentrations, and the effect of pretreatment with(-)-3-PPP(2mg/kg) on the haloperidol(2mg/kg)-induced extracellular dopamine concentrations in the nucleus accumbens(NAS) of free moving rats.

 Methods：Dopamine levels in dialysate were determined with high pressure liquid chromatography(HPLC) with electrochemical detection(ECD). 

 Results：(1)(-)-3-PPP had dual actions depending on the doses: at 2mg/kg, it decreased and at 10mg/kg, increased extracellular dopamine concentrations；(2) haloperidol at all doses increased dopamine levels with higher dose having a greater increase; and(3) pretreatment of(-)-3-PPP reduced the increase in dopamine levels elicited by acute treatment with haloperidol. 

 Conclusions：These findings suggest that pretreatment of(-)-3-PPP in low dose could accelerate the onset of therapeutic effect of haloperidol by diminishing the haloperidol-induced dopamine release in the limbic system. 

Keywords (-)-3-PPP;Haloperidol;Dopamine;Nucleus accumbens.