Oct, 1, 2023

Vol.30 No.2, pp. 84-88

Current Issue Archives
Search
Advanced Search
Editorial Office

Review

  • Korean Journal of Biological Psychiatry
  • Volume 8(1); 2001
  • Article

Review

Korean Journal of Biological Psychiatry 2001;8(1):106-10. Published online: Jan, 1, 2001

Abstract PDF Full Text

The Association between the Dopamine D1 Receptor Genotype and Treatment Response in Korean Schizophrenic Patients

  • Jong Woo Paik, MD1;Min Soo Lee, MD, PhD1;Choong Soon Rhee, MD, PhD2;Dong Ju Lim, MD1;and Won Hun Ham, PhD3;
    1;Department of Psychiatry, College of Medicine, Korea University, Seoul, 2;Yong-In Mental Hospital, Kyunggi-do, 3;Sungkyunkwan University School of Pharmacy, Seoul, Korea
Abstract

Background：Dopamine receptors have been regarded as a strong candidate involved in etiology of schizophrenia and a target for various antipsychotic drugs. The purpose of our study was to investigate whether dopamine D1 receptor(DRD1) gene polymorphisms would predict the treatment response to antipsychotics in schizophrenia. 

 Method : One hundred thirty-four schizophrenic patients, who met DSM-IV criteria for schizophrenia were entered into a 48 -week study. The psychopathology of the patients was assessed at baseline, 12th, 24th 48th weeks of treatment by PANSS. Responders were defined by a 20% of the reduction in total PANSS score at end point. The genomic DNA fragment corresponding to nucleotides of dopamine D1 receptor gene was amplified by polymerase chain reaction(PCR).

 Result: Neither allelic frequencies nor genotypes for dopamine D1 receptor differed significantly between responders and non-responders. Also, there was no difference of changes of PANSS scores among three genotype groups of the dopamine D1 receptor.

 Conclusion : Allelic variation in the dopamine D1 gene is not associated with individual differences in antipsychotic response.

Keywords Dopamine D<sub>1</sub> receptor;Receptor gene;Schizophrenia;Treatment response.