Korean Journal of Biological Psychiatry

Objectives：Although polymorphisms of apolipoprotein E have been investigated in many neuropsychiatric disorders, results were controversial and even contradictory. The purpose of this study was to investigate the genotypes of apolipoprotein E in schizophrenia and healthy controls, and to compare them in two groups in terms of distribution of apolipoprotein E genotype and allele.

Method：Using polymerase chain reaction and amplified refractory mutation system, apolipoprotein E genotypes were identified in 77 schizophrenics and 115 healthy control persons.

Results：The results were as follows 1) When genotypes of apolipoprotein E were classified into ε2/2, ε2/3, ε2/4, ε3/3, ε3/4, ε4/4 according to phenotypes, there were no statistical differences in genotypes between two groups 2) In terms of allele frequency, there were also no statistical differences between two groups

Conclusion：These results suggest that genotypes and alleles of apolipoprotein E seem to be unrelated to the pathogenesis of schizophrenia.

Keywords Apolipoprotein E;Schizophrenia;Genotypes.