Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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  • Korean Journal of Biological Psychiatry
  • Volume 11(2); 2004
  • Article

Review

Korean Journal of Biological Psychiatry 2004;11(2):88-93. Published online: Feb, 1, 2004

Abstract PDF Full Text

An Association Study of the 5-HTTLPR and COMT Genes Polymorphisms and Personality Traits

  • Jee-Hyun Ha, MD1;Byung-Joo Ham, MD2;Sung-Gon Ryu, MD2;Tae-Yeon Hwang, MD1;Jong-Gook Lee, MD1;Yu-Sang Lee, MD1;Jung-Sik Lee, MD1;Dae Yeob Kang, MD1;Ihn-Geun Choi, MD2; and Min Soo Lee, MD3;
    1;Yong-In Psychiatric Research Institute, Yongin, 2;Department of Neuropsychiatry, College of Medicine, Hallym University, Chuncheon, 3;Department of Psychiatry, College of Medicine, Korea University, Seoul, Korea
Abstract

Background：Serotonin transporter gene-linked polymorphism region(5-HTTLPR) and catechol-O-methyl-transferase(COMT) genes are thought to be important factors in some personality traits and the etiology of anxiety disorder. The goal of this study was to determine the role of these genes in personality traits.

Method：The participants included 116 healthy adults with no history of psychiatric disorders and other physical illness for the last 6 months. All participants were tested by Temperament and Character Inventory(TCI). The 5-HTTLPR, COMT val158met gene polymorphisms were analyzed with PCR(Polymerase Chain Reaction). Differ-ences on TCI dimensions and sub-scales among groups were examined with t-test and ANOVA.

Result：There were possible relationships of the 5-HTTLPR with self-transcendence(P=0.050) and COMT val158met polymorphism with cooperativeness(P=0.053).

Conclusion：We found associations between 5-HTTLPR, COMT polymorphisms and the some TCI character dimensions. Further studies of polymorphisms of other genes and their interactions may clarify the complex relationship between personality and genes.

Keywords Temperament and Character Inventory;5-HTTLPR;COMT;Personality traits;Genetic polymorphism.