Oct, 1, 2023

Vol.30 No.2, pp. 84-88

Current Issue Archives
Search
Advanced Search
Editorial Office

Review

  • Korean Journal of Biological Psychiatry
  • Volume 11(2); 2004
  • Article

Review

Korean Journal of Biological Psychiatry 2004;11(2):146-54. Published online: Feb, 1, 2004

Abstract PDF Full Text

A Family-Based and Case-Control Association Study of the Serotonin 1B Receptor Gene Polymorphism in Korean Attention Deficit Hyperactivity Disorder

  • Tae Won Park, MD, PhD1,6;Boong Nyun Kim, MD, PhD2;Myung-Ho Im, MD, PhD3;Hee Jeong Yoo, MD, PhD4;Daehee Kang, MD, PhD5; and Young-Chul Chung, MD, PhD6;
    1;Research Institute of Clinical Medicine, Chonbuk National University, Jeonju, 2;Division of Child & Adolescent Psychiatry, Department of Psychiatry, College of Medicine, Seoul National University, Seoul, 3;Department of Psychiatry, College of Medicine, Dankook University, Cheonan, 4;Department of Psychiatry, College of Medicine, Gyeongsang National University, Jinju, 5;Department of Preventive Medicine, College of Medicine, Seoul National University, Seoul, 6;Department of Psychiatry, College of Medicine, Chonbuk National University, Jeonju, Korea
Abstract

Objective：Attention deficit hyperactivity disorder(ADHD) is the most common childhood psychiatric disorder, affecting 3-5% of school-aged children. Although the biological basis of ADHD is unknown, family studies provide strong evidence that ADHD has a genetic basis. Recent genetic studies have suggested associations between ADHD and serotonin 1B(5HT1B) receptor gene G861C polymorphism. The aim of this study is to test for the association between ADHD and 5HT1B receptor gene G861C polymorphism in Korean population.

Method：We processed DNA extraction and genotyping. 106 Korean children with ADHD and their parents were analyzed using the transmission disequilibrium test(TDT) and haplotype-based haplotype relative risk(HHRR). And the ADHD children were compared with 212 age and gender matched normal controls.

Results：There was no statistical difference of distributions between ADHD cases and controls. We did not observe any preferential transmission of alleles of 5HT1B receptor gene G861C polymorphism in ADHD.

Conclusions：Though there is the possibility of failing to detect small genetic effects, our results show no evidence of an association between ADHD and 5HT1B receptor gene G861C polymorphism in the Korean population and indicate that it is unlikely that the 5HT1B receptor is implicated in the susceptibility to ADHD.

Keywords Attention deficit hyperactivity disorder(ADHD);Serotonin;5HT1B receptor;G861C polymorphism;Association study.