Oct, 1, 2023

Vol.30 No.2, pp. 84-88

Current Issue Archives
Search
Advanced Search
Editorial Office

Review

  • Korean Journal of Biological Psychiatry
  • Volume 12(1); 2005
  • Article

Review

Korean Journal of Biological Psychiatry 2005;12(1):62-7. Published online: Jan, 1, 2005

Abstract PDF Full Text

The CDH2 Gene Polymorphism in Schizophrenia

  • Won Seok Lee, MD1;Mi Kyung Kim, MD, PhD1;Han Yong Jung, MD, PhD2;Sung Il Woo, MD, PhD2;Young Joon Kwon, MD, PhD2;Jong Woo Kim, MD, PhD3; and Hee Je Lee, PhD4;
    1;Seoul National Mental Hospital, Seoul, 2;Department of Psychiatry, College of Medicine, Soonchunhyang University Hospital, Buchoen, 3;Department of Neuropsychiatry, College of Medicine, Kyunghee University Hospital, Seoul, 4;Department of Pharmacology, College of Medicine, Kangwon University Hospital, Chuncheon, Korea
Abstract

Objective：There has been increasing evidence that neurodevelopmental dysfunction is involved in the pathophysiology of schizophrenia. Cadherin is known to be one of the important molecules in neurodevelopment. This study was performed to examine the relationship between T816C polymorphism of CDH2 gene and schizophrenia.

Methods：Genoytypes of T816C polymorphism of CDH2 gene were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 156 Korea patents with schizophrenia and 170 controls.

Results：No difference was found between the patients with schizophrenia and the controls in genotype and allele frequencies of T816C polymorphism of CDH2 gene.

Conclusion：The results of this study do not support an association between T816C polymorphism of CDH2 gene and schizophrenia. However, it is necessary to investigate other polymorphic regions of CDH2 in schizophrenia.

Keywords CDH2;Polymorphism;Schizophrenia.