Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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  • Korean Journal of Biological Psychiatry
  • Volume 13(2); 2006
  • Article

Review

Korean Journal of Biological Psychiatry 2006;13(2):110-6. Published online: Feb, 1, 2006

Abstract PDF Full Text

Microarray Analysis of Gene Expression in Rat Hippocampus of Maternal Social Separation Model

  • Hee Jae Lee, PhD1;Chang Hee Son, MD1;Hyong Ryol Kwak1;Sang-Hyun Lee, MS1;Yoon Hee Han, MD1;Soo Young Kim, MD1;Jong-Ik Park, MD, PhD2;Wanjoo Chun, PhD1; and Sung-Soo Kim, MD, PhD1;
    1;Department of Pharmacology, 2;Psychiatry, College of Medicine, Kangwon National University, Chuncheon, Korea
Abstract

Objectives：Alteration of hippocampus was demonstrated in the maternal social separation(MSS) pups, se-parated from dams on postnatal day(pnd) 14 and placed alone. Therefore, to understand the molecular events involved in the MSS, we have initiated a search for gene profiles that are up or down-regulated in the hippocampus of MSS pups.

Methods：Analysis of cDNA microarray was performed by using total RNA extracted from the hippocampus of control and MSS pups on pnd 17. Also, passive-avoidance test was demonstrated on pnd 35.

Results：Up-regulation of Nedd4a was observed in the hippocampus of MSS pups. Also, MSS rats showed less elongation of latency in passive avoidance test. 

Conclusion：We suggest that environmental effects of MSS may be altered the neural and/or glial differentiation and synapse formation-related genes which may lead cognitive alterations in MSS rats.

Keywords Maternal social separation;Microarray;<i>Nedd4a</i>;Memory.