Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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Review

  • Korean Journal of Biological Psychiatry
  • Volume 13(3); 2006
  • Article

Review

Korean Journal of Biological Psychiatry 2006;13(3):137-43. Published online: Mar, 1, 2006

Abstract PDF Full Text

P50 and Schizophrenia

  • Seung-Hwan Lee, MD, PhD;Hyung-Seok Seo, MD; and Young-Cho Chung, MD, PhD
    Department of Psychiatry, Ilsanpaik Hospital, Inje University of Korea, Goyang, Korea
Abstract

One of the most widely recognized neurophysiologic endophenotypes for schizophrenia is deficient gating or inhibition of the P50 component of the auditory event-related potential(ERP). A deficit in P50 sensory gating refers to a dysfunction in the mechanism responsible for modulating the brain's sensitivity of filtering out irrelevant or background stimuli, perhaps as a result of dysfunction in inhibitory neural circuits. In this paper, we review the neuronal and genetic aspects as well as medication effects on P50 in schizophrenia.

Keywords P50;Event-related potential;ERP;Schizophrenia.