Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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  • Korean Journal of Biological Psychiatry
  • Volume 13(3); 2006
  • Article

Review

Korean Journal of Biological Psychiatry 2006;13(3):162-9. Published online: Mar, 1, 2006

Abstract PDF Full Text

Brain-Derived Neurotrophic Factor(BDNF) Genetic Polymorphism and the Long-term Outcome of Antidepressant Treatment in Korean Depressive Patients

  • Jae-Woo Koo, MD1;Hwa-Young Lee, MD2;Jong-Woo Paik, MD1;Rhee-Hun Kang, MD1; and Min-Soo Lee, MD, PhD1;
    1;Department of Psychiatry, Depression Center and Pharmacogenomic Research Center for Psychotropic Drugs, 2;Department of Psychiatry, Korea University College of Medicine, Ansan Hospital, Ansan, Korea
Abstract

Objective：Since some studies have shown that the brain-derived neurotrophic factor(BDNF) has an important role in the pathophysiology of depression, this study investigated the relationship between BDNF genetic polymorphism and the long-term outcome of the antidepressant treatment.

　

Method：One hundred and eight patients with major depressive disorder were evaluated for the long-term outcome(up to 3 years) of antidepressant treatment. The severity and improvement of depression were assessed with the Clinical Global Impression(CGI) Scale. The genotypes of BDNF 196A/G polymorphism in the patients were determined using Restriction Fragment Length Polymorphism(RFLP).

　

Result：The genotypes of 128 patients were investigated and 95 patients of those have been evaluated for 3 years. No significant differences were noted comparing three-genotype groups for CGI scales at baseline, 4 weeks, 8 weeks, 1 year, 2 years and 3 years.

　

Conclusion：This result shows that BDNF polymorphism investigated in this study was not associated with the long-term outcome of the antidepressant treatment. However, further studies with another BDNF polymorphism should be needed. 

Keywords Depression;Brain-Derived Neurotrophic Factor;Polymorphisms;Antidepressive agents;Pharmacogenetics.