Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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  • Korean Journal of Biological Psychiatry
  • Volume 13(3); 2006
  • Article

Review

Korean Journal of Biological Psychiatry 2006;13(3):178-90. Published online: Mar, 1, 2006

Abstract PDF Full Text

Relationship between Alcohol Withdrawal Symptoms and Dopaminergic Gene Polymorphisms(DRD2, DAT, COMT) in Alcohol Dependence Patients

  • Tai Young Choi, MD, PhD1;Ho-Nam Kim, MD1;Doug-Hyun Han, MD, PhD2;Kyung-Jun Min, MD, PhD1;Young-Sik Lee, MD, PhD1; and Chul Na, MD, PhD1;
    1;Department of Neuropsychiatry, Chung-Ang University School of Medicine, Seoul, 2;Department of Neuropsychiatry, Seoul University School of Medicine, Seoul, Korea
Abstract

Objectives：We investigated the relationship of the alcohol withdrawal symptoms with genetic polymorphism among alcohol dependence patients.

　

Method：The measuring instruments used in this study were the Clinical Institute Withdrawal Assessment for Alcohol(CIWA-Ar). We analyzed DRD2 TaqI A polymorphism, dopamine transporter(DAT 1) polymorphism, and catechol-O-methyltransferase(COMT) polymorphism in 108 male alcoholics and 76 healthy controls.

　

Results：The major findings was as follows. No significant differences for genotype distribution or allele frequency were revealed comparing controls and alcoholic patients. 
DRD2 Taq I：The subscale score of auditory hallucination among CIWA-Ar scale in homozygote was significantly higher than in heterozygote(OR=1.34). The total score of CIWA-Ar scale in heterozygote was significantly higher than in homozygote. DAT1：In the subject without DAT-9 gene allele, it was significantly higher of the subscale score of sweating, anxiety among CIWA-Ar scale than in the subject with DAT-9 gene allele. And The total score of CIWA-Ar scale in the subject without DAT-9 gene allele was significantly higher than in the subject with DAT-9 gene allele. COMT：The total score of CIWA-Ar scale in heterozygote was significantly higher than in homozygote.

　

Conclusion：Our results suggest the relationship between specific genetic factors and the withdrawal symptoms of alcohol dependent patients. As the candidate gene of the severity of alcohol withdrawal syndrome, DRD2 Taq1 gene was recommended.

Keywords Alcohol withdrawal;Genetic polymorphism;CIWA-Ar.