Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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  • Korean Journal of Biological Psychiatry
  • Volume 13(4); 2006
  • Article

Review

Korean Journal of Biological Psychiatry 2006;13(4):279-88. Published online: Apr, 1, 2006

Abstract PDF Full Text

Relationship between SNP A and P1763 Polymorphisms on Dystrobrevin Binding Protein 1(DTNBP1) Gene and Smooth Pursuit Eye Movement(SPEM) Abnormality in Korean Schizophrenic Patients

  • Chang Hee Lee, MD1;Byung-Lae Park, PhD2;Lyoung Hyo Kim, PhD2;Dong Hyeon Kim, MD3;Sook Hyun Cho, MD1;Jin-Soo Park, MD4;Im-Yel Kim, MD4;In-Sang Lee, MD5;Han-Gil Seo, MD5;Ki-Ook Byun, MD6;Bong-Jo Kim, MD7;Kyu-Hee Hahn, MD7;Ki-Hoon Kim, MA8;Tae-Min Shin, PhD8;Hyung Doo Shin, PhD2; and Sung-Il Woo, MD1;
    1;Department of Psychiatry, Soon Chun Hyang University Hospital, Seoul, 2;SNP Genetics, Seoul, 3;Division of Mental Health, Ministry of Health and Welfare, Gwacheon, 4;Keyo Hospital, Euiwang, 5;Jinju Mental Hospital, Jinju, 6;Hadong Wooridle Hospital, Hadong, 7;Department of Psychiatry, Gyeongsang National University Hospital, Jinju, 8;Department of Biomedical Engineering, Yonsei University, Wonju, Korea
Abstract

Objectives：We investigated the association of SNP A and P1763 polymorphisms on dystrobrevin binding protein 1(DTNBP1) gene with smooth pursuit eye movement(SPEM) abnormality in Korean schizophrenic patients.

Methods：We measured SPEM function in 217 Korean schizophrenics(male 116, female 101) and divided them into two groups, one is a good SPEM function group and the other is a poor SPEM function group. We then analyzed SNP A polymorphism and P1763 polymorphism on DTNBP1 gene from their DNAs extracted from their blood. We compared the differences of genotype and allele distributions of the two polymorphisms on DTNBP1 gene between the two groups.

Results：The Ln S/N ratio(mean±SD) of the good SPEM function group was 4.39±0.33 and the ratio of poor SPEM function group was 3.17±0.71. There were no statistically significant differences of age and male/female ratio between the two groups. There were no significant differences of genotype or allele distributions of the SNP A polymorphism and P1763 polymorphism on DTNBP1 gene between the two schizophrenic groups divided by SPEM function.

Conclusion：The results suggest that SNP A polymorphism and P1763 polymorphism on DTNBP1 gene might not be related to SPEM function abnormality in schizophrenia.

Keywords Schizophrenia;Dystrobrevin binding protein 1(DTNBP1);Smooth pursuit eye movement (SPEM);Genetic polymorphism.