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2021 Impact Factor 1.766
5-Year Impact Factor 1.674
Korean Journal of Biological Psychiatry 1995;2(2):237-47. Published online: Feb, 1, 1995
The finding of contrasting results regarding an association between schizophrenia and the MluI polymorphism site in the dopamine D3 receptor gene prompted us to study the distribution of this polymorphism in Korean schizophrenic patients and controls. The author;s approach was case-control study. Schizophrenic patients(n=66) and controls(n=76) were examined by case-control study for distribution of the MluI polymorphism of the dopamine D3 receptor gene in Korean population to minimize the effect of racial differencies in gene frequencies. The frequency of the allele 1 in Schizophrenic patients and controls was 0.66 and 0.76, respectively. There was no significant differencies in the frequency of the allele 1 between schizophrenic pateitns and controls(x2=3.07, p>.05), and between positive and negative schizophrenic patients(x2=1.02, p>.05). We present here the evidence of a loack of alleic association between the MluI polymorphism of the dopamine D3 receptor gene and Korean schizophrenic patients and also report no increased homozygosity for the MluI polymorphism. The assumption that the dopamine D3 receptor gene has a predisposing role in schizophrenia was not supported by this case-control study. Although, the possibility that this gene has a minor gene effects in the etiology of schizophrenia cannot be excluded because of the intrinsic limitations of the methods of analysis and number of subjects in our study.
Keywords Schizophrenia;Case-control study;Dopamine D<sub>3</sub> receptor;Association.