Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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  • Korean Journal of Biological Psychiatry
  • Volume 14(4); 2007
  • Article

Review

Korean Journal of Biological Psychiatry 2007;14(4):262-7. Published online: Apr, 1, 2007

Abstract PDF Full Text

No Association between the 5-HT6 Receptor C267T Polymorphism and Response to Citalopram Treatment in Patient with Major Depressive Disorder

  • Sang-Woo Hahn, MD1;Se-Won Lim, MD2;Kang-Seob Oh, MD2;Rhee-Hun Kang, MD3; and Min-Soo Lee, MD3;
    1;Department of Psychiatry, Soonchunhyang University of College of Medicine, Seoul, 2;Department of Psychiatry, Sungkunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, 3;Department of Psychiatry, Korea University College of Medicine, Seoul, Korea
Abstract

The serotonin 6(5-HT6) receptor gene is a candidate gene for influencing the clinical response to treatment with antidepressants. The purpose of this study was to determine the relationship between the C267T polymorphism in the 5-HT6 receptor gene and the treatment response to citalopram in a Korean population with major depressive disorder(MDD).

Methods：Citalopram was administered for 8 weeks to the 90 patients who completed study. 21-item Hamilton depression rating scale(HAMD-21) was used as a outcome measure.

Results：We found that the genotype, allele, and allele-carrier distributions did not differ significantly between MDD patients and normal controls. A main effect of an interaction of genotype with time on the decrease in the HAMD-21 score during the 8 weeks study period was not found. ANOVA revealed no significant effects of the C825T polymorphism on the decrease in the HAMD-21 score at each time period.

Conclusions：These results suggest that the C267T polymorphism in the 5-HT6 receptor gene is not associated with the treatment response to citalopram.

Keywords Major depressive disorder;5-HT6 receptor;C267T polymorphism;Citalopram.