Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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  • Korean Journal of Biological Psychiatry
  • Volume 15(1); 2008
  • Article

Review

Korean Journal of Biological Psychiatry 2008;15(1):5-13. Published online: Jan, 1, 2008

Abstract PDF Full Text

An Association Between Apolipoprotein E ε4 and Cognitive Function in Community-Dwelling Elders with Questionable Dementia*

  • Seok Woo Moon, MD, PhD1;Jeong Seok Seo, MD, PhD1;Beom Woo Nam, MD, PhD1;Jin Young Choi, MD, PhD2;Chang Hoon Lee, MD, PhD3;Kyoung Un Park, MD, PhD4; and Ki Woong Kim, MD, PhD5;
    1;Department of Neuropsychiatry, 2;Neurology, 3;Laboratory Medicine, School of Medicine Kunkuk University, Chungju Hospital, Chungju, 4;Department of Laboratory Medicine, 5;Neuropsychiatry, Seoul National University College of Medicine, Bundang Hospital, Seongnam, Korea
Abstract

Objectives：It was the aim of the present paper to examine the impact of the apolipoprotein E(APOE) ε4 on cognitive performance in community-dwelling elderly samples with 'questionable dementia'.

Methods：Total 295 samples who were diagnosed with 'questionable dementia' in the recent year and completed the Korean version of the Consortium Establish a Registry for Alzheimer's Disease(CERAD-K) neuropsychological assessment protocol, were recruited. The CDR test established score of 0.5. Genomic DNA was extracted from the venous blood and APOE genotyping was done in this group. Their cognitive performance was compared by the occurrence of the APOE ε4 allele.

Results：The impact of ε4 allele was significant in the Word List Recall Test(WLRT, F=4.511, df=1, p=0.035). The 'young-old' group aged 75 years and under had a significantly lower performance on the Word List Recall Test(WLRT, F=5.090, df=1, p=0.015), but the 'old-old' group over 75 years of age had not significantly different performance on the all the item of tests in ε4+ allele group.

Conclusion：The conclusion to be drawn here is that community-dwelling elderly samples with ε4 allele in 'questionable dementia' had a significantly lower performance on the Word List Recall Test in the CERAD-K neuropsychological test batteries and the effect was prominent in the 'young-old' age group.

Keywords CDR;Apolipoprotein E;CERAD-K;Neuropsychological test.