Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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Review

  • Korean Journal of Biological Psychiatry
  • Volume 15(2); 2008
  • Article

Review

Korean Journal of Biological Psychiatry 2008;15(2):110-7. Published online: Feb, 1, 2008

Abstract PDF Full Text

Neural Substrates of Posttraumatic Stress Disorder：Functional Magnetic Resonance Imaging Study Using Negative Priming Task

  • Byeong-Taek Lee, PhD1,2;Jeong Ryu2,3;Dong Hoon Lee4;Myeong-Ho Sohn, PhD5;Nae Hee Kang, PhD6;Byung-Joo Ham, MD, PhD7; and Nam Hee Choi, PhD2,8;
    1;Institute of Psychological Science, Seoul National University, Seoul, 2;Seoul Institute for Narrative Studies, Seoul, 3;Cognitive Science Program, Graduate School, Yonsei University, Seoul, Korea, 4;Department of Psychology, Indiana University, IN, 5;Department of Psychology, George Washington University, Washington D.C., MA, USA, 6;Department of English Language and Literature, Chung Ang University, Seoul, 7;Department of Psychiatry, Hangang Sacred Heart Hospital, Hallym University Medial Center, Seoul, 8;Seoul Wemen's College of Nursing, Seoul, Korea
Abstract

Objectives：Posttraumatic stress disorder(PTSD) has been primarily associated with emotional problems. Recently, however, the impact of PTSD on cognitive processes has interested a growing number of researchers. The current study is aimed at investigating the cognitive aspects of PTSD at both behavioral and neurological levels.

Methods：We recruited individuals with PTSD who survived the Daegu subway explosion in 2003 as well as non-PTSD individuals as a control group. To evaluate the inhibitory processes and the neural mechanisms, we had these individuals perform the negative priming task simultaneously with functional MRI scanning.

Results：Behaviorally, the negative priming effect was intact in the control group but was not evident in the PTSD group. In the imaging results, only the PTSD group showed the negative priming effect (i.e., increased activation of the negative priming condition as opposed to the neutral condition) in the dorsolateral prefrontal cortex, anterior cingulate cortex, and inferior temporal gyrus. The PTSD group also showed increased activity for the positive priming condition as opposed to the neutral condition in the claustrum. These results confirm and extend the previous findings that the integrity of the ACC is compromised in the trauma survivors due to disrupted white matter tract.

Conclusions：The current results suggest that deteriorated performance of the PTSD group may be due to the functional problem as well as the structural abnormalities.

Keywords Posttraumatic stress disorder;Functional magnetic resonance imaging;Negative priming task;Anterior cingulate gyrus.