Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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  • Korean Journal of Biological Psychiatry
  • Volume 15(4); 2008
  • Article

Review

Korean Journal of Biological Psychiatry 2008;15(4):288-96. Published online: Apr, 1, 2008

Abstract PDF Full Text

No Association between Val108/158Met Polymorphism on Catechol-O-Methyl Transferase(COMT) Gene and Smooth Pursuit Eye Movement(SPEM) Abnormality in Korean Schizophrenia Patients

  • Ho Joon Jang, MD1;Hyun-Il Moon, MD1;Yeon Jung Lee, MD1;Im-Yel Kim, MD2;In-Sang Lee, MD3;Han-Gil Seo, MD3;Ki-Hoon Kim, MA4;Tae-Min Shin, PhD4;Byung-Lae Park, PhD5;Hyung Doo Shin, PhD5,6;Sun Ho Han, MD1;Sang-Woo Han, MD1; and Sung-Il Woo, MD1;
    1;Department of Neuropsychiatry, College of Medicine, Soonchunhyang University, Seoul, 2;Keyo Hospital, Euiwang, 3;Jinju Mental Hospital, Jinju, 4;Department of Biomedical Engineering, Yonsei University, Wonju, 5;SNP Genetics, Seoul, 6;Department of Life Science, Sogang University, Seoul, Korea
Abstract

Objectives：We investigated the association of Val108/158Met polymorphism on catechol-O-methyl transferase(COMT) gene with smooth pursuit eye movement(SPEM) abnormality in Korean schizophrenia patients.

Methods：We measured SPEM in 217 Korean schizophrenia patients(male 116, female 101) and divided them into two groups, one was a good SPEM function group and the other was a poor SPEM function group. Then we analyzed Val108/158Met polymorphism on COMT gene. We compared the differences of genotype and allele distributions of the polymorphism on COMT gene between the two groups.

Results：The natural logarithm value of signal/noise ratio(Ln S/N ratio) of the good SPEM function group was 4.39±0.33(mean±s.d.) and that of poor SPEM function group was 3.17±0.71. There were no statistically significant differences of age and male/female ratio between the two groups. There were no significant differences of genotype or allele distributions of the Val108/158Met polymorphism on COMT gene between the two schizophrenic groups.

Conclusions：The results suggest that Val108/158Met polymorphism on COMT gene is not related to SPEM function abnormality in schizophrenia.

Keywords Schizophrenia;Catechol-O-methyl transferase(COMT);Smooth pursuit eye movement(SPEM);Genetic polymorphism.