Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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  • Korean Journal of Biological Psychiatry
  • Volume 15(4); 2008
  • Article

Review

Korean Journal of Biological Psychiatry 2008;15(4):303-9. Published online: Apr, 1, 2008

Abstract PDF Full Text

Association of the 5-HT5A Receptor Gene Polymorphisms and Citalopram Response in Korean Patients with Major Depressive Disorder

  • Jin-Hyun Shim, MD, PhD1;Jong-Woo Paik, MD, PhD2;Jeung-Woong Oh, MD3;Rhee-Hun Kang, MD4;Hwa-Young Lee, MD4; and Min-Soo Lee, MD, PhD4;
    1;Apple-tree Psychiatric Clinic, Seoul, 2;Department of Psychiatry, Kyunghee University College of Medicine, Seoul, 3;Department of Psychiatry, Seoul Metropolitan Eunpyeong Hospital, Seoul, 4;Department of Psychiatry, Korea University College of Medicine, Seoul, Korea
Abstract

Objectives：Some reports have suggested that 5-HT5A polymorphism allelic association was associated with depression, however, there has been no report about relationship between the 5-HT5A gene and antidepressant response. We conducted the association study of the 5-HT5A receptor gene polymorphisms (-19G/C,12A/T) and response to citalopram in Korean patients with major depressive disorder(MDD).

Methods：A total of 106 patients with major depressive disorder were included in this study. The patient's symptoms were measured by 21-item Hamilton Depression Rating Scale(HAMD) at baseline, week 1, week 2, week 4 and week 8 during citalopram treatment. A Responder to citalopram was defined by 50% reduction of total HAMD scores. To analyze genetic polymorphisms, a polymerase chain reaction based method was used.

Results：At week 8, responders were 62, non-responders were 44. No significant differences of genotypes or allelic association in 19G/C and 12A/T polymorphisms were observed between responsive and non-responsive patients.

Conclusion：These results do not support the hypothesis that this polymorphism of the HT5A receptor gene is involved in the therapeutic response to citalopram.

Keywords Depression;5HT5A receptor;Polymorphism;Citalopram;Pharmacogenetics.