Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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  • Korean Journal of Biological Psychiatry
  • Volume 16(3); 2009
  • Article

Review

Korean Journal of Biological Psychiatry 2009;16(3):149-58. Published online: Mar, 1, 2009

Abstract PDF Full Text

Association Analysis of Polymorphisms on Dystrobrevin Binding Protein 1(DTNBP1) Gene with Schizophrenia in the Korean Population

  • Hyun-Il Moon, MD1;Yeon Jung Lee, MD1;Byung-Lae Park, PhD2;Hyung Doo Shin, PhD2;Ihn-Geun Choi, MD3;Sun Ho Han, MD1; and Sung-Il Woo, MD1;
    1;Department of Neuropsychiatry, College of Medicine Soonchunhyang University, Soonchunhyang University Hospital, Seoul, 2;SNP Genetics, Seoul, 3;Department of Neuropsychiatry, Hallym University College of Medicine, Hangang Sacred Heart Hospital, Seoul, Korea
Abstract

Objectives：This study was designed to investigate the association of schizophrenia and P1320, P1325, P1635, P1655, P1763 and SNP A polymorphisms on dystrobrevin binding protein 1(DTNBP1) gene in Korean patients.

Methods： We analyzed P1320, P1325, P1635, P1655, P1763 and SNP A polymorphisms on DTNBP1 gene from their DNAs extracted from their blood in 388 Korean schizophrenic patients (male 198, female 190) and 372 control subjects(male 247, female 125). We compared the differences of genotype and allele distributions of the six polymorphisms on DTNBP1 gene between the Korean schizophrenic patient group and the normal control group. 

Results：There were no statistically significant differences of genotype and allele distributions of the P1320, P1325, P1635, P1655, P1763 and SNP A polymorphisms on DTNBP1 gene between the schizophrenic patient group and the normal control group.

Conclusion：The results of this study suggest that P1320, P1325, P1635, P1655, P1763 and SNP A polymorphism on DTNBP1 gene do not have influence on the risk of the schizophnenic in the Korean population.

Keywords Dystrobrevin Binding Protein 1(DTNBP1);Schizophrenia;Genetic polymorphism.