Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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  • Korean Journal of Biological Psychiatry
  • Volume 16(3); 2009
  • Article

Review

Korean Journal of Biological Psychiatry 2009;16(3):190-7. Published online: Mar, 1, 2009

Abstract PDF Full Text

Gray Matter Changes in Patients with Pathological Gambling：A Preliminary Study Using Voxel-Based Morphometry Study

  • Jung-Seok Choi, MD1,2;Young-Chul Shin, MD, PhD3;Wi Hoon Jung, MS4;Myung Hun Jung, MD1;Joon Hwan Jang, MD1;Do-Hyung Kang, MD, PhD1;Chi-Hoon Choi, MD5;Jun Soo Kwon, MD, PhD1,4,6; and Jun-Young Lee, MD, PhD1,2;
    1;Department of Psychiatry, Seoul National University College of Medicine, Seoul, 2;Department of Neuropsychiatry, SMG-SNU Boramae Medical Center, Seoul, 3;Department of Psychiatry, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul, 4;Interdisciplinary Program in Brain Science, Seoul National University, Seoul, 5;Department of Radiology, National Medical Center, Seoul, 6;Brain & Cognitive Science-WCU program, College of Natural Science, Seoul National University, Seoul, Korea
Abstract

Objectives：The purpose of this study was to examine structural abnormalities of brain in patients with pathological gambling(PG) using voxel-based morphometry.

Methods：We compared gray matter(GM) volumes between 10 patients with PG and 14 age- and IQ-matched healthy controls and examined the relationship of GM volumes with clinical variables in patients with PG.

Results：We found significant increase of GM volume in the superior, middle, and inferior frontal gyri, the midbrain, the middle temporal gyrus, the precuneus, and the fusiform gyrus of patients with PG. A significant decrease of GM volume was observed in the parahippocampal gyrus and the lingual gyrus of the patient group. In addition, GM volumes in some of these regions were positively associated with South Oaks Gambling Screen score and negatively with age of onset in patients with PG.

Conclusion：Current findings indicate that structural abnormalities in the fronto-temporal cortex, the midbrain, and the precuneus might be involved in the pathophysiology of PG, and contribute to some of the behavioral changes observed in patients with PG.

Keywords Pathological gambling;Voxel-based morphometry.