Oct, 1, 2023

Vol.30 No.2, pp. 84-88

Current Issue Archives
Search
Advanced Search
Editorial Office

Review

  • Korean Journal of Biological Psychiatry
  • Volume 17(3); 2010
  • Article

Review

Korean Journal of Biological Psychiatry 2010;17(3):127-35. Published online: Mar, 1, 2010

Abstract PDF Full Text

Comparative Study on Initial Symptoms Using Single Photon Emission Computer Tomography in Schizophrenia

  • Jin-Gu Lee, MD1;Seong-Min Kim, MD2;Young-Duk Seo, MD2;Ki-Seong Kim, MS3;Seong-Keun Wang, MD1;Ik-Seung Chee, MD1; and Jeong-Lan Kim, MD1;
    1;Department of Psychiatry, School of Medicine, Chungnam National University, Daejeon, 2;Department of Nuclear Medicine, School of Medicine, Chungnam National University, Daejeon, 3;Laxtha Institute of Technology, Daejeon, Korea
Abstract

Objectives：This study was conducted to compare between hallucination group and delusion group in patient with schizophrenia, using Brain 99mTc-ECD SPECT.


Methods：Among 16 patients with less than 3 schizophrenic episodes, 8 patients whose initial symptom was hallucination were assigned to the hallucination group, and other 8 patients with initial sumptom of delusion were assinged to the hallucination group. All of the patients clinically evaluated using the PANSS and BPRS. Both groups of patients and 8 healthy subjects underwent 99mTc-ECD SPECT.


Results：Score of thinking disturbance subscale of BPRS were significantly lower in the hallucination group than the delusion group. In SPECT analysis, the hallucination group showed significantly increased perfusion in some areas of the right temporal lobe, bilateral limbic lobes and left parietal lobe compared to delusion group. Both group had a reduced rCBF in some areas of the frontal lobe.


Conclusion：The hallucniation group, compared with the delusion group, showed significantly increased regional cerebral blood flow in some regions. Therefore, this data suggests that different neural substrates may affect the process of auditory hallucination and delusion.

Keywords <sup><i>99m</i></sup>Tc-ECD SPECT;Brain;Hallucination;Delusion;Schizophrenia;Perfusion.