Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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  • Korean Journal of Biological Psychiatry
  • Volume 17(4); 2010
  • Article

Review

Korean Journal of Biological Psychiatry 2010;17(4):210-7. Published online: Apr, 1, 2010

Abstract PDF Full Text

A Correlation of Cognitive Function, Depression, Suicidal Idea and Serum Lipid Levels in the Elderly Over Sixty Years of Age

  • Jung-Joon Moon, MD1; Bong-Ju Lee, MD, PhD1; Jeong-Eun Kim, MD1; Woo-Jin Kim, MD1; Min-Hyo Kim, MD1; Min-Kyong Park, MD1; Tae-Hong Song, MD1; Joo-Cheol Shim, MD, PhD1; Gyung-Mee Kim, MD1; Jung-Goo Lee, MD, PhD1,2; and Young-Hoon Kim, MD, PhD1,2;
    1;Department of Psychiatry, Inje University College of Medicine, Busan, 2;Paik Institute for clinical research, Inje University, Busan, Korea
Abstract

Objectives：We investigated a correlation of cognitive function, depression, suicidal idea and serum lipid levels in Korean elderly over 60 years old to find risk factors of deprssion and cognitive decline.


Methods：834 persons participated in this study. Clinical evaluation was done at a point by using Mini-Mental State Examination in the Korean version of CERAD assessment packet(MMSE-KC). We also evaluated 165 persons that agreed to our exact examination for Geriatric Depression Scale(GDS), Scale for Suicidal Ideation(SSI), Hachinski Ischemic Score and serum lipid profile. Correlation analysis was used to evaluate correlation among serum lipid levels, MMSE-KC and SSI. One-way ANOVA was used for comparison of serum lipid levels and cognitive function, depression and SSI. We did a post-hoc analysis.


Results：Depression and suicidal ideation were related with cognitive impairment in Korean elderly over 60 years old. Those who have more severe cognitive impairment and depressive symptom, have higher Hachinski ischemic score. We can see high HDL cholesterol levels only in the normal control group. Low total, HDL, LDL cholesterol were related with depression.


Conclusion：There was high prevalence of depression in the Korean elderly over 60 years old and low serum lipid level was related with severity of depression and high suicidal ideation. In the normal control group, we can see high HDL cholesterol levels. To confirm this result, we need well-designed and wide range study.

Keywords Cognitive function;Geriatric depression;Suicidal ideation;Serum lipid level.