Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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  • Korean Journal of Biological Psychiatry
  • Volume 18(4); 2011
  • Article

Review

Korean Journal of Biological Psychiatry 2011;18(4):254-9. Published online: Apr, 1, 2011

Abstract PDF Full Text

Right Caudate Volumetric Differences in Young Healthy Adults with Different Dopamine DRD2/ANKK1 Taq 1a Polymorphisms

  • Yujin Jeon, MD1; Yera Choi, BA1; Jihyun H. Kim, MD1; Jiyoung J. Jung, MD1; Dajung J. Kim, BA1; Sukgyeong Yu2; Jooyeon Jamie Im, BA2; and Junghyun H. Lee, MD1;
    1;Department of Psychiatry, Seoul National University College of Medicine, Seoul, 2;Department of Life Sciences, Ewha Womans University College of Natural Sciences, Seoul, Korea
Abstract

Objectives：The aim of this study was to assess variations in caudate volume according to dopamin receptor D2/ankyin repeat and kinase domain containing 1 (DRD2/ANKK1) Taq 1a polymorphisms in young healthy adults and to evaluate the relationship between caudate volumes and psychiatric symptoms as measured by the Brief Psychiatric Rating Scale.


Methods:Genetic information regarding DRD2/ANKK1 Taq 1a and T1-weighted brain magnetic resonance images were acquired from 30 young healthy adults. Automatic segmentation of caudate was performed using the FreeSurfer program. 


Results:Individuals with A2 homozygotes of DRD2/ANKK1 Taq 1a polymorphisms (n = 10) had greater right caudate volumes compared to those with A1 allele (s)(18.4% greater ; p = 0.019). Right caudate volumes were negatively associated with total scores of the Brief Psychiatric Rating Scale (ß=-0.50 ; p = 0.016).


Conclusions:Our findings suggest the possibility that DRD2/ANKK1 Taq 1a polymorphisms may underlie the psychiatric symptoms by influencing the structure of the right caudate.

Keywords DRD2/ANKK1 Taq 1a polymorphism ;Caudate;Brief psychiatric rating scale;Magnetic resonance imaging.