Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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  • Korean Journal of Biological Psychiatry
  • Volume 19(1); 2012
  • Article

Review

Korean Journal of Biological Psychiatry 2012;19(1):53-7. Published online: Jan, 1, 2012

Abstract PDF Full Text

Association Study between DRD2 Genetic Polymorphisms and Schizophrenia in a Korean Population

  • Tae-Sung Kim, MD1;Seung-Min Cha, MD1;Seong-Keun Wang, MD2;Jeong-Lan Kim, MD2;Young-Ho Lee, MD3;Hye-In Choi, MS3; and Ik-Seung Chee, MD2;
    1;Department of Psychiatry, Chungnam National University Hospital, Daejeon, 2;Departments of Psychiatry, 3;Anatomy, School of Medicine, Chungnam National University, Daejeon, Korea
Abstract

Objectives : This study was designed to investigate the association between the dopamine D2 receptor (DRD2) genetic polymorphism [TaqIB (rs17294542) and TaqID (rs1800498)] and patients with schizophrenia.

Methods : TaqIB (rs17294542) and TaqID (rs1800498) polymorphism of the DRD2 gene were typed in 100 patients with schizophrenia and 109 normal controls.

Results : There were no statistical differences in genotype and allele distribution of TaqIB (rs17294542) and TaqID (rs1800498) genetic polymorphism between patients with schizophrenia and normal controls.

Conclusions : These results suggest that the TaqIB (rs17294542) and TaqID (rs1800498) polymorphisms of the DRD2 gene may not be associated with schizophrenia in the Korean population.

Keywords Schizophrenia;<i>DRD2</i>;Genetic polymorphism;Association study.