Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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  • Korean Journal of Biological Psychiatry
  • Volume 19(3); 2012
  • Article

Review

Korean Journal of Biological Psychiatry 2012;19(3):128-33. Published online: Mar, 1, 2012

Abstract PDF Full Text

Association Analysis of Neuregulin 3(NRG3) Gene with Schizophrenia in a Korean Population

  • Sujin Shin, MD1;Jong-Taek Choi, MD1;Ji-Won Kim, MD1;Yang-Ho Roh, MD1;Byung-Lae Park, PhD2;Joon Seol Bae, PhD3;Hyoung Doo Shin, PhD3;Ihn-Geun Choi, MD4;Sang-Woo Han, MD1;Jaeuk Hwang, MD1; and Sung-Il Woo, MD1;
    1;Department of Psychiatry, College of Medicine, Soonchunhyang University, Soonchunhyang University Hospital, Seoul, 2;Department of Genetic Epidemiology, SNP Genetics, Inc., Seoul, 3;Department of Life Science, Sogang University, Seoul, 4;Department of Neuropsychiatry, Hallym University College of Medicine, Hangang Sacred Heart Hospital, Seoul, Korea
Abstract

Objectives : Located on chromosome 10q22-q23, the human neuregulin 3 (NRG3) is suggested as a strong positional and functional candidate gene involved in the pathogenesis of schizophrenia. Several case-control studies examining the association between polymorphisms on NRG3 gene with schizophrenia and/or its traits (such as delusion) have been reported recently in cohorts of Han Chinese, Ashkenazi Jews, Australians, white Americans of Western European ancestry and Koreans. Thus, this study aimed to investigate the association of one SNP in exon 9 (rs2295933) of NRG3 gene with the risk of schizophrenia in a Korean population.

Methods : Using TaqMan assay, rs2295933 in the exon 9 of NRG3 was genotyped in 435 patients with schizophrenia as cases and 393 unrelated healthy individuals as controls. Differences in frequency distributions were analyzed using logistic regression models following various modes of genetic inheritance and controlling for age and sex as covariates.

Results : Subsequent analysis revealed that the frequency distribution of rs2295933 of NRG3 was not different between schizophrenia patients and healthy controls of Korean ethnicity.

Conclusions : This study does not support the role of NRG3 in schizophrenia in a Korean population.

Keywords <i>NRG3</i>;Schizophrenia;Single nucleotide polymorphism;rs2295933.