Oct, 1, 2023

Vol.30 No.2, pp. 84-88

Current Issue Archives
Search
Advanced Search
Editorial Office

Review

  • Korean Journal of Biological Psychiatry
  • Volume 19(3); 2012
  • Article

Review

Korean Journal of Biological Psychiatry 2012;19(3):140-5. Published online: Mar, 1, 2012

Abstract PDF Full Text

Association Analyses of ST8SIA2 Genetic Polymorphisms with Schizophrenia in the Korean Population

  • Jae Hyun Yoo, MD1;Seunghyong Ryu, MD1;Eun Young Cho, MS2;Ik-Soo Huh, BS3;Taesung Park, PhD3;Yu-Sang Lee, MD4;Jun Soo Kwon, MD5; and Kyung Sue Hong, MD1,2;
    1;Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, 2;Samsung Biomedical Research Institute, Center for Clinical Medicine, Seoul, 3;Department of Statistics, College of Natural Science, Seoul National University, Seoul, 4;Yong-In Mental Hospital, Yongin, 5;Department of Psychiatry, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea
Abstract

Objectives : ST8SIA2 (ST8 alpha-N-acetyl-neuraminide alpha-2, 8-sialyltransferase 2 gene) is located at 15q26, a susceptibility locus for schizophrenia. Some previous research had indicated that single-nucleotide polymorphisms (SNPs) in the promoter region of ST8SIA2 were associated with schizophrenia in Japanese and Chinese populations. We investigated the association between SNPs in the promoter region of ST8SIA2 and schizophrenia in the Korean population.

Methods : The study subjects were 190 Korean patients with schizophrenia and 190 healthy controls. We performed allelic, genotypic, and haplotypic association analyses for rs3759916, rs3759915 and rs3759914 of ST8SIA2. All genotypes were determined by direct sequencing.

Results : In the genotype-based analysis, rs3759914 showed a nominally significant association with schizophrenia under recessive genotypic model (p = 0.047). However, this association did not remain statistically significant after correction for multiple testing. Both allelic and haplotype analyses did not show any significant association.

Conclusions : These findings suggest that ST8SIA2 does not play a major role in the susceptibility to schizophrenia in the Korean population. Further studies with a larger number of subjects are required to definitively rule out minor effects of this gene on schizophrenia vulnerability.

Keywords <i>ST8SIA2</i>;Schizophrenia;Genetic polymorphism;Association.