Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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  • Korean Journal of Biological Psychiatry
  • Volume 19(4); 2012
  • Article

Review

Korean Journal of Biological Psychiatry 2012;19(4):193-8. Published online: Apr, 1, 2012

Abstract PDF Full Text

Relationship between Serum Inflammatory Marker and Psychotic Symptoms in Inpatients with Schizophrenia or Schizoaffective Disorder

  • Kye Hwan Kim, MD1;Kounseok Lee, MD1,2;Su Jin Kim, MD2,3;Eun Kyu Lee, MD1;Yul-mai Song, RN2; and Jin Young Park, MD4,5;
    1;Department of Psychiatry, Gongju National Hospital, Gongju, 2;Neuropsychiatry Research Laboratory, Gongju National Hospital, Gongju, 3;Department of Internal Medicine, Gongju National Hospital, Gongju, 4;Department of Psychiatry, Yonsei University College of Medicine, Seoul, 5;Institute of Behavioural Science in Medicine, Yonsei University College of Medicine, Seoul, Korea
Abstract

Objectives : Despite the growing research interest in the role of immunological markers in schizophrenia, a few studies, with conflicting results, have focused on the association between high sensitivity C-reactive protein (hs-CRP) levels and clinical characteristics in schizophrenia. The aim of the present study was to examine the association of serum hs-CRP with psychopathology in schizophrenia.

Methods : Fifty-five inpatients with schizophrenia or schizoaffective disorder were enrolled. Serum levels of hs-CRP were measured, and each patient was assessed with the Korean version of the Positive and Negative Syndrome Scale (PANSS).

Results : In correlation analysis of hs-CRP with PANSS subscales, positive subscale score has significant positive correlation (r = 0.271, p = 0.046). In independent t-test analysis, subjects with hs-CRP > 0.3 mg/dL (elevated CRP group, n = 43) had significantly higher PANSS positive subscale score (t = -3.273, df = 24.107, p = 0.003) than those with hs-CRP ≤ 0.3 mg/dL (normal CRP group, n = 12).

Conclusions : Elevated serum levels of high sensitivity C-reactive protein in schizophrenia are associated with the severity of psychotic symptoms.

Keywords C-reactive protein;Inflammatory marker;Schizophrenia;Positive symptoms.