Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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  • Korean Journal of Biological Psychiatry
  • Volume 3(1); 1996
  • Article

Review

Korean Journal of Biological Psychiatry 1996;3(1):51-56. Published online: Jan, 1, 1996

Abstract PDF

Time-Course of [3H]Spiperone Binding and Dopamine Metabolism in the Rat Striatum after Withdrawal from Haloperidol Treatment

  • Jung-Yong Lee, MD1;Bo-Geum Long, MD1;Yong-Kwan Kim, MD1;Chung Jung, MD2;Sun-Hee Kim, MD3; and Young-Hoon Kim, MD1;
    1;The Institute of Neuroscience and Department of Neuropsychiatry, School of Medicine, Inje University, Paik Hospital, Pusan, 2;Department of Neuropsychiatry, Dong Seu Hospital, Masan, 3;The Institute of Neuroscience, Inje University, Pusan, Korea
Abstract

The effects of 3 week treatment with haloperidol(2mg / kg / day, i.p.) on dopamine(DA) D2 receptor and DA metabolism in rat striata were studied at various time points after withdrawal form the drug treatment. Striatal DA D2 receptors were characterized with the radioligand 0.5nM [3H]spiperone. Dopamine(DA), homovanillic acid(HVA), 3,4-dihydroxyphenyl acetic acid(DOPAC) in rat striatum were measured with the high performance liquid chromatography. Drug withdrawal for 1 week induced significant increase in the number of D2 receptor in striatum after withdrawal for 1 week(p<0.05), and then this change was restored to control level during the withdrawal time of 2 and 4 weeks. There was no difference in striatal concentrations of DA and its metabolites among the groups. In conclusion, one-week withdrawal from chronic haloperidol treatment induced DA D2 receptor supersensitivity in the srtiatum, and that was normalized rapidly. Though this adaptive change in DA receptors, it may not affect the metabolism of DA in striatum.

Keywords Dopamine receptor supersensitivity;[<sup>3</sup>H]spiperone binding;Haloperidol withdrawal.