Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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Review

  • Korean Journal of Biological Psychiatry
  • Volume 20(3); 2013
  • Article

Review

Korean Journal of Biological Psychiatry 2013;20(3):91-6. Published online: Mar, 1, 2013

Abstract PDF Full Text

Association Study between Treatment Response of Amisulpride and Dopamine D3 Receptor Gene Polymorphisms

  • Seung-Gul Kang, MD1;Heon-Jeong Lee, MD2;Seung Jae Lee, MD3;Tae Young Choi, MD4;Jungmin Woo, MD4;Jihyun Kim, MD4;Sung-Won Jung, MD5;Bon Hoon Koo, MD6;Kwanghun Lee, MD7;Jeong-Lan Kim, MD8;Ik-Seung Chee, MD8,9; and Jonghun Lee, MD4;
    1;Department of Psychiatry, Gil Medical Center, Gachon University School of Medicine, Incheon, 2;Department of Psychiatry, Korea University College of Medicine, Seoul, 3;Department of Psychiatry, Kyungpook National University School of Medicine, Daegu, 4;Department of Psychiatry, Catholic University of Daegu School of Medicine, Daegu, 5;Department of Psychiatry, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, 6;Department of Psychiatry, College of Medicine, Yeungnam University, Daegu, 7;Department of Psychiatry, Dongguk University College of Medicine, Gyeongju Hospital, Gyeongju, 8;Department of Psychiatry, School of Medicine, Chungnam National University, Daejeon, 9;Institute of Brain Research, Chungnam National University, Daejeon, Korea
Abstract

Objectives : The aim of this study is to evaluate the association between rs6280 and rs905568 genetic polymorphism of DRD3 gene and the treatment response of amisulpride.

Methods : After six weeks treatment of amisulpride, 125 schizophrenia patients were interviewed based on the Positive and Negative Syndrome Scale (PANSS) and the Clinical Global Impression-Severity (CGI-S). The genotyping for rs6280 and rs905568 was performed using TaqMan single nucleotide polymorphism (SNP) genotyping assay.

Results : There was no significant difference in the frequency of genotype and allele of rs6280 between the responders and non-responders based on the total, positive, and general score of PANSS and CGI-S score. However, there was a significant association between this SNP and treatment response in the negative score of PANSS (χ2 = 5.23, p = 0.022). There was no significant association between rs905568 and the response in positive, negative, general, and total PANSS score and CGI-S score.

Conclusions : This is the first positive association study between DRD3 gene and the treatment response of negative symptoms to amisulpride in Korean schizophrenia patients. A larger scale research on more SNP of the DRD3 gene will make a progress in the study of pharmacogenetics on the treatment response of the amisulpride.

Keywords Treatment response;Amisulpride;<i>DRD3</i> gene;Polymorphisms;<i>rs</i>6280.