Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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Review

  • Korean Journal of Biological Psychiatry
  • Volume 22(2); 2015
  • Article

Review

Korean Journal of Biological Psychiatry 2015;22(2):34-9. Published online: Feb, 1, 2015

Abstract PDF Full Text

Neuroglia and Mood Disorder

  • Jung Goo Lee, MD1,2,3;Mi Kyong Seo, PhD2;Sung Woo Park, PhD2,3; and Young Hoon Kim, MD1,2,3;
    1;Department of Psychiatry, Haeundae Paik Hospital, College of Medicine, Inje University, Busan, 2;Paik Institute for Clinical Research, Inje University, Busan, 3;Department of Health Science and Technology, Graduate School of Inje University, Busan, Korea
Abstract

Mood disorder is a common psychiatric illness with a high lifetime prevalence in the general population. A serious problem such as suicide is commonly occurring in the patients with depression. Till now, the monoamine hypothesis has been the most popular theory of pathogenesis for depression. However, the more specific pathophysiology of depression and cellular molecular mechanism underlying action of commercial antidepressants have not been clearly defined. Several recent studies demonstrated that glial cells, especially astrocytes, are a promising answer to the pathophysiology of depression. In this article, current understanding of biology and molecular mechanisms of glial cells in the pathology of mood disorder and new research on the pathophysiology of depression will be discussed.

Keywords Mood disorder;Glial cell;Astrocyte;Pathophysiology;Antidepressants.