Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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Review

  • Korean Journal of Biological Psychiatry
  • Volume 22(4); 2015
  • Article

Review

Korean Journal of Biological Psychiatry 2015;22(4):173-8. Published online: Apr, 1, 2015

Abstract PDF Full Text

Association Study of ANK3 Polymorphism and Risk of Schizophrenia

  • So Yung Yang, MD1;Ik-Soo Huh, BS2;Eun Young Cho, MS3;Mi Ji Choi, BS3;Taesung Park, PhD2;Yu-Sang Lee, MD4; and Kyung Sue Hong, MD1,3;
    1;Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, 2;Department of Statistics, Seoul National University, Seoul, 3;Center for Clinical Research, Samsung Biomedical Research Institute, Seoul, 4;Yong-In Mental Hospital, Yongin, Korea
Abstract

Objectives : Previous genome-wide association studies have indicated the association between ankyrin 3 (ANK3) and the vulnerability of schizophrenia. We investigated the association between single nucleotide polymorphisms (SNPs) covering the whole ANK3 locus and schizophrenia in the Korean population.

Methods : The study subjects were 582 patients with schizophrenia and 502 healthy controls. Thirty-eight tag SNPs on ANK3 and five additional SNPs showing significant association with schizophrenia in previous studies were genotyped.

Results : Three (rs10994181, rs16914791, rs1938526) of 43 SNPs showed a nominally significant association (p < 0.05) with at least one genotype model. But none of these associations remained significant after adjusting for multiple testing errors with Bonferroni's correction.

Conclusions : We could not identify a significant association between ANK3 and schizophrenia in the Korean population. However, three SNPs showing an association signal with nominal significance need to be investigated in future studies with higher statistical power and more specific phenotype crossing the current diagnostic categories.

Keywords <i>ANK3</i>;Schizophrenia;Genetic association study.