Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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Review

  • Korean Journal of Biological Psychiatry
  • Volume 22(4); 2015
  • Article

Review

Korean Journal of Biological Psychiatry 2015;22(4):223-32. Published online: Apr, 1, 2015

Abstract PDF Full Text

The Correlation of Levels of Serum Lipid, Homocysteine, and Folate with Volumesof Hippocampus, Amygdala, Corpus Callosum, and Thickness of Entorhinal Cortexin Patients with Amnestic Mild Cognitive Impairment or Dementiaof Alzheimer’s Type

  • Sang Jun Lee, MD1;Tae Hyung Kim, MS2;Lyang Huh, MD1;Seung Eun Choi, MA3;Bong Ju Lee, MD1;Gyung Mee Kim, MD1;Jung Goo Lee, MD1;Hong Dae Kim, MD4;Chi Woong Mun, PhD2; and Young Hoon Kim, MD1;
    1;Department of Psychiatry, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, 2;Department of Biomedical Engineering, and U-Health Care Research Center, Inje University, Gimhae, 3;Department of Psychology, Inje University Haeundae Paik Hospital, Busan, 4;Department of Radiology, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea
Abstract

Objectives : In this study, the authors evaluated the correlation between levels of serum lipid, homocysteine, and folate with volumes of hippocampus, amygdala, corpus callosum, and in patients with amnestic mild cognitive impairment (aMCI) or Alzheimer's disease (AD) type.

Methods : The study recruited patients who visited the dementia clinic of Haeundae Paik Hospital in Korea between March 2010 and June 2014. Among those, patients who had taken the neurocognitive test, brain magnetic resonance imaing, tests for serum lipid, homocysteine, folate, and apolipoprotein E (APOE) genotyping and diagnosed with aMCI or AD were included for analysis. Bilateral hippocampus, entorhinal cortex, amygdala and corpus callosum were selected for region of interest (ROI). The cross-sectional relationships between serum lipid, homocysteine, folate and ROI were assessed by partial correlation analysis and multiple linear regression analysis.

Results : In patients with aMCI, old age (> 80) and APOE ε4 carrier were associated with AD [odds ration (OR) : 12.80 ; 95% confidence interval (CI) : 2.25-72.98 and OR : 4.48 ; 95% CI : 1.58-12.67, respectively]. In patients with aMCI or AD, volumes and thickness of ROI were inversely correlated with levels of serum lipid and homocysteine. In multiple linear regression analyses, higher total cholesterol level was related to lower left, right hippocampus volume and left amygdala volume ; higher low-density lipoprotein cholesterol was related to lower right entorhinal cortex thickness ; higher homocysteine level was related to lower corpus callosum volume.

Conclusions : Higher serum lipid and homocysteine levels are associated with decreased volume of hippocampus, amygdala, corpus callosum and entorhinal cortex thickness in patients with aMCI or AD. These findings suggest that serum lipid and homocysteine levels are associated with AD as a modifiable risk factor.

Keywords Alzheimer’s disease;Mild cognitive impairment;Cholesterol;Homocysteine.