Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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Review

  • Korean Journal of Biological Psychiatry
  • Volume 23(1); 2016
  • Article

Review

Korean Journal of Biological Psychiatry 2016;23(1):24-8. Published online: Jan, 1, 2016

Abstract PDF Full Text

Role of p11 (S100A10) in Depression and Antidepressant Effects

  • Sung Woo Park, PhD1,2;Mi Kyong Seo, PhD1;Jung Goo Lee, MD1,2,3; and Young Hoon Kim, MD1,2,3;
    1;Paik Institute for Clinical Research, Inje University College of Medicine, Busan, 2;Department of Health Science and Technology, Graduate School of Inhe University, Busan, 3;Department of Psychiatry, Haeundae Paik Hospital and College of Medicine, Inje University, Busan, Korea
Abstract

p11 protein (S100A10) is downregulated in depressive-like states of human and rodent. Antidepressant drug treatment increases p11 levels in rodent models. We reviewed studies demonstrating that p11 levels are regulated in depression and by antidepressant treatment and that p11 upregulation exerts antidepressant effects. Current studies on p11 underscore the importance of p11 as a potential antidepressant target.

Keywords p11;Depression;Antidepressant;Antidepressant effects.