Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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Review

  • Korean Journal of Biological Psychiatry
  • Volume 3(1); 1996
  • Article

Review

Korean Journal of Biological Psychiatry 1996;3(1):115-120. Published online: Jan, 1, 1996

Abstract PDF

c-fos Expression of Rat Brain by Antipsychotics : Contrasting Effects of Haloperidol and Clozapine

  • Min Soo Lee, MD1;Chang Su Han, MD1;Jeung Hyun Kim, PhD1;Young Tae Kim, MD2; and Dong Il Kwak, MD1;
    1;Department of Neuropsychiatry, Korea University College of Medicine, Seoul, 2;Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea
Abstract

To investigate characteristic drug effects on the genetic basis, the authors administered haloperidol- the D2 antagonist- and clozapine -the atypical antipsychotics with few extra- pyramidal side effects- to the rats. Then, we edobtain brain specimen from the striatum, prefrontal cortex, and cortical region and compared the degree of c-fos expression. The results are 1) haloperidol was found to produce a rapid and transient induction of c-fos mRNA expression in striatum as compared with cortex and prefrontal area. 2) clozapine was found to produce rapid induction of c-fos mRNA in striatum and prefrontal area. 
3)From these data, we can concluded that the mechanism of action of haloperidol is different from the mechanism of clozapine in gene expression.

Keywords Haloperidol;Clozapine;c-fos.