Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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Review

  • Korean Journal of Biological Psychiatry
  • Volume 24(1); 2017
  • Article

Review

Korean Journal of Biological Psychiatry 2017;24(1):1-9. Published online: Jan, 1, 2017

Abstract PDF Full Text

Animal Models of Demyelination and 1H-Magnetic Resonance Spectroscopy

  • Han Byul Cho, PhD1;Suji Lee, BS2,3;Shinwon Park, MA2,3;Ilhyang Kang, MS2,3;Jiyoung Ma, MS2,4;Hyeonseok S. Jeong, PhD5;Jieun E. Kim, MD2,3;Sujung Yoon, MD2,3;In Kyoon Lyoo, MD2,3,6;Soo Mee Lim, MD,2,7; and Jungyoon Kim, MD2,3;
    1;The Brain Institute, University of Utah, Salt Lake City, UT, USA, 2;Ewha Brain Institute, Ewha Womans University, Seoul, 3;Department of Brain and Cognitive Sciences, Division of Convergence, Scranton College, Ewha Womans University, Seoul, 4;Interdisciplinary Program in Neuroscience, College of Natural Sciences, Seoul National University, Seoul, 5;Department of Radiology, The Catholic University of Korea, Incheon St. Mary's Hospital, Incheon, 6;Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 7;Department of Radiology, Ewha Womans University School of Medicine, Seoul, Korea
Abstract

The proton magnetic resonance spectroscopy (1H-MRS) is a tool used to detect concentrations of brain metabolites such as N-acetyl aspartate, choline, creatine, glutamate, and gamma-amino butyric acid (GABA). It has been widely used because it does not require additional devices other than the conventional magnetic resonance scanner and coils. Demyelination, or the neuronal damage due to loss of myelin sheath, is one of the common pathologic processes in many diseases including multiple sclerosis, leukodystrophy, encephalomyelitis, and other forms of autoimmune diseases. Rodent models mimicking human demyelinating diseases have been induced by using virus (e.g., Theiler's murine encephalomyelitis virus) or toxins (e.g., cuprizon or lysophosphatidyl choline). This review is an overview of the MRS findings on brain metabolites in demyelination with a specific focus on rodent models.

Keywords Proton magnetic resonance spectroscopy;Demyelination;Animal models.