Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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Review

  • Korean Journal of Biological Psychiatry
  • Volume 3(1); 1996
  • Article

Review

Korean Journal of Biological Psychiatry 1996;3(1):121-6. Published online: Jan, 1, 1996

Abstract PDF

Prolactin Response to Cimetidine in the Schizophrenics -In Unmedicated Male Positive and Negative Patients-

  • Hyuk Hee Jin, MD; Young Joon Kwon, MD; Hee Yeon Jeong, MD; and Sun Ho Han, MD;
    Department of Neuropsychiatry, Soon-Cheon-Hyang University College of Medicine, Chun-An, Korea
Abstract

Object : There is considerable interest in the role of serotonin(5-HT) in the pathophysiology of schizophrenia. Cimetidine, H2 antagonist, produces transient increase in serum prolactin(PRL) levels by indirect serotonergic mechanism in man following intravenous administration. Therefore the authors investigated the effects of cimetidine on serum PRL levels of male unmedicated schizophrenics.


Method : Baseline serum prolactin level and psychopathology were measured at 9 : 00 AM. in the two groups(12 positive schizophrenics, 7 negative schizophrenics) and T30 level were measured 30 minutes after intravenous injection of cimetidine(ie, 9 : 30 AM)


Result : 1) Baseline prolactin levels were not different in the three groups. 2) prolactin levels of 30 minutes after intravenous injection of cimetidine(T30) compared with baseline prolactin levels were increased all in the three groups. 3) Degrees of interval change from baseline to T30 were significantly different between normal control and negative schizophrenics(p<0.05).


Conclusion : The prolactin response to cimetidine was significantly blunted in negative male schizophrenics than normal control. These data are consistent with the hypothesis of an abnormality of serotonergic activity, including down-regulation of 5-HT2 receptors, in male negative schizophrenics.

Keywords Cimetidine;Prolactin Serotonin;5-HT receptor;Schizophrenia.