Oct, 1, 2023

Vol.30 No.2, pp. 84-88

Current Issue Archives
Search
Advanced Search
Editorial Office

Review

  • Korean Journal of Biological Psychiatry
  • Volume 30(1); 2023
  • Article

Review

Korean Journal of Biological Psychiatry 2023;30(1):17-23. Published online: Apr, 1, 2023

Abstract PDF Full Text

DOI : https://doi.org/10.22857/kjbp.2023.30.1.003

Chronic Reserpine Administration for Depression Modeling in Zebrafish

  • Seyoung Kim, MD,1 Changsu Han, MD, PhD,2 Young-Hoon Ko, MD, PhD,1
    Yong-Ku Kim, MD, PhD,1 Ho-Kyoung Yoon, MD, PhD,1 Jongha Lee, MD, PhD,1
    Suhyun Kim, PhD,3,4 Chanhee Lee, PhD,4 Cheolmin Shin, MD, PhD1,4
    1 Department of Psychiatry, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea
    2 Department of Psychiatry, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea
    3 Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Korea
    4 Zebrafish Translational Medical Research Center, Korea University, Ansan, Korea
Abstract

Objectives  This study aims to develop valid experimental models for depression through chronic reserpine exposure to zebrafish (Danio rerio).
Methods  The effect of chronic reserpine on zebrafish behavior in the novel tank was examined. Changes of gene expression on telencephalon were also investigated.
Results  Chronic reserpine (40 mg/L, 7 days) induced overt behavioral effects, but markedly reduced activity, resembling motor retardation in depression. In telencephalon of zebrafish, gene expression associated with monoamine oxidase and norepinephrine transporter was decreased. Expression of serotonin transporter gene was increased.
Conclusions  Our results show that the pharmacological model of depression in zebrafish can induce not only behavioral changes, but also monoamine changes in the homology of human mood regulation centers.

Keywords Reserpine; Depression; Zebrafish; Animal model; Experimental model.