Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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Review

  • Korean Journal of Biological Psychiatry
  • Volume 3(2); 1996
  • Article

Review

Korean Journal of Biological Psychiatry 1996;3(2):245-50. Published online: Feb, 1, 1996

Abstract PDF

The Binding Study of 125I-LSD to Platelet Membrane in Alcoholism

  • Young Chul Chung, MD; and Hong Bai Eun, MD
    Department of Psychiatry, Institute for Medical Sciences, Chonbuk National University Medical School, Chonju, Korea
Abstract

This research was performed to find out the changes of serotonin receptors in the platelet of alcoholics. Using 125I-LSD as a radioligand. We obtained the following results. 1) In the comparison of patients vs controls, Bmax of the former was significantly higher than that of the latter(p=0.0017). But there was no significant difference in the Kd between the two groups. 2) In the comparison of type 1 vs type 2, alcoholics by cloninger's classification Bmax of the latter was significantly higher than that of the former(p=0.0396). But there was no significant difference in the Kd between the two groups. 3) In the comparison of alcohol abuse vs alcohol dependence, there were no significant differences in the value of Bmax and Kd between the two groups. These results support the hypothesis of serotonin-deficit in alcoholism. Furthermore, it can be inferred that the increase of platelet serotonin receptors in alcoholics might be used as a trait marker. 

Keywords Alcoholism;Serotonin-deficit hypothesis;<sup>125</sup>I-LSD;Serotonin receptor;Trait marker.