Korean Journal of Biological Psychiatry

The results regarding an association between the polymorphism sites in the dopamine D₁ receptor gene and schizophrenia compelled us to study the distribution of the polymorphism in Korean schizophrenia and controls. Eighty-eight schizophrenic patients and normal controls were examined by case-control study for distribution of the polymorphism of the dopamine D₁ receptor gene in Korean popualtion to minimize the effect of racial differencies in gene frequencies. The frequencies of the B₁ and B₂ in schizophrenic patients were 0.11 and 9.89, respectively. And 0.10 and 0.90 in normal control. Ther was no significant differences in the frequencies in the allele B₁ and B₂ between schizophrenic patients and normal controls. The author present here the evidence of a lack of alleic association between the polymorphism of the dopamine D₁ receptor gene and Korean schizophrenic patients. The assumption that the dopamine D₁ receptor gene has a genetic role in the development of schizophrenia was not suppoorted by this case-control study.

Keywords Schizophrenia;Dopamine D1 receptor;Alleic association.