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Review

  • Korean Journal of Biological Psychiatry
  • Volume 5(1); 1998
  • Article

Review

Korean Journal of Biological Psychiatry 1998;5(1):122-8. Published online: Jan, 1, 1998

Abstract PDF Full Text

A Clinical Trial of Combined Treatment with Estrogen and Antipsychotics in Females with Chronic Schizophrenia

  • Ei-Jung Kwon, MD1;Jin-Se Kim, MD1;Dong-Woo Lee, MD2; and In-Kwa Jung,MD1;
    1;Department of Neuropsychiatry, College of Medicine, Korea University, Seoul, 2;Pusan Dong-In Hospital, Pusan Korea
Abstract

Objective：This study was a open clinical trial aimed at exploring the effectiveness of combined treatment with estrogen and antipsychotics to the chronic female schizophrenics.

Method：40 female patients who met DSM-Ⅵ criteria for schizophrenia who were chronically ill were randomly assigned to estrogen group(EG) and control group(CG). EG patients were received estrogen 1.25mg for 8weeks in addition to their routine antipsychotic regimens. CG patients were received their routine antipsychotic regimens only. Both groups were evaluated by PANSS(Postive and Negative Syndrome Scale), CGI(Clinical Global Impression) at 0, 4, 8 week during the trial period and compaired with each other.

Results：40 female patients have completed the study during 8weeks. EG was significantly improved in PANSS and CGI scores than CG during the 8weeks. In EG patients, all symptom subtypes(positive symptoms, negative symptoms, general psychopathology symptoms) of PANSS were significantly improved and positive symptoms were most significantly improved at 8week.

Conclusions：This results support the clinical value of combined estrogen therapy among chronic female schizophrenics.

Keywords Estrogen;Schizophrenia;Combined treatment.