Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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Review

  • Korean Journal of Biological Psychiatry
  • Volume 6(1); 1999
  • Article

Review

Korean Journal of Biological Psychiatry 1999;6(1):89-95. Published online: Jan, 1, 1999

Abstract PDF Full Text

Association of Tardive Dyskinesia with Cognitive Deficit in Schizophrenia

  • Tae-Seob Jang, MD3;Byoung-Hoon Oh, MD2; and Jin-Sook Cheon, MD1;
    1;Department of Neuropsychiatry, Kosin University, School of Medicine, Pusan, 2;Department of Neuropsychiatry, Yonsei University, College of Medicine, Seoul, 3;Dong Nam Psychiatric Hospital, Kimhae, Korea
Abstract

To understand a mechanism of underlying cognitive deficit in schizophrenia, the risk factors, cognitive function, blood dopamine concentrations and glutamate dehydrogenase activities of male schizophrenics with tardive dyskinesia(N＝30) were compared with those of schizophrenics without tardive dyskinesia(N＝30). The results were as following；1) The age, duration of illness and duration of medication were significantly more in schizophrenics with tardive dyskinesia than schizophrenics without tardive dyskinesia(respectively p<0.005, p<0.0001, p<0.0001). 2) The scores of MMSE, TIQ, VIQ and PIQ were significantly lower in schizophrenics with tardive dyskinesia than schizophrenics without tardive dyskinesia(rspectively p<0.0001). 3) Plasma dopamine concentrations were tended to be higher, and serum glutamate dehydrogenase activities were tended to be lower in schizophrenics with tardive dyskinesia than schizophrenics without tardive dyskinesia. 4) The cognitive deficit seemed to be negatively correlated with duration of illness and duration of medication(respectively γ＝-0.496, γ＝-0.615).

Keywords Schizophrenia;Tardive dyskinesia;Cognitive deficit.