Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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Review

  • Korean Journal of Biological Psychiatry
  • Volume 7(2); 2000
  • Article

Review

Korean Journal of Biological Psychiatry 2000;7(2):159-63. Published online: Feb, 1, 2000

Abstract PDF Full Text

The Association between the Dopamine D5 Receptor Genotype and Treatment Response for KoreanSchizophrenic Patients

  • Sung Min Kang, MD1;Min Soo Lee MD, PhD1; and Choong Soon Rhee, MD, PhD2;
    1;Department of Psychiatry, College of Medicine, Korea University, Seoul, 2;Yong-In Mental Hospital, Kyunggi-do, Korea
Abstract

Background：Dopamine receptors are strong candidates for involvement in schizophrenia and are target of a wide variety of antipsychotics. Dopamine D5 receptor(DRD5) gene polymorphisms may be associated with various treatment response. The purpose of our study was define to what significance can be held as a predictor of treatment response in this polymorphism.

 Method：The total number of 116 Korean chronic schizophrenic patients was assessed after 48 weeks treatment. The Positive and Negative Syndrome Scale(PANSS) was rated for the clinical response to various antipsychotics. With the use of polymerase chain reaction amplification, we assessed this dopamine D5 receptor polymorphism in schizophrenic patients who had been treated with antipsychotics, and related genotype with treatment response, to test the hypothesis that DRD5 polymorphism may lead to varying response to antipsychotics.

 Result：DRD5 polymorphism was not associated with treatment response to a variety of antipsychotics in chronic schizophrenic patients.

 Conclusion：Genetic variation of D5 receptors do not predict treatment response to antispychotics.

Keywords Dopamine D<sub>5</sub> receptor;Receptor gene;Schizophrenia;Treatment response.