Korean Journal of Biological Psychiatry

Objective：The present study was designed to compare Global Field Power Measurement and conventional method in P300 determination.

Method：The subjects were composed of patients(N＝20) with schizophrenia by DSM-IV and normal controls(N＝20). The auditory event related potential P300 was measured by “oddball paradigm”. P300 components were determined by Global Field Power Measurement and conventional method at 5 electrodes(Fz, Cz, Pz, T₃, T₄).

Results：P300 amplitudes of patients were smaller than those of controls across all electrodes and in both methods, but there was no differential power in P300 determination between two methods. Asymmetry of auditory event-related potential P300 was not shown between patients with schizophrenia and normal controls.

Conclusion：It is implicated that it depends on clinical situations and research purposes what method of P300 determination will be more appropriate for patients with schizophernia.