Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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Review

  • Korean Journal of Biological Psychiatry
  • Volume 8(1); 2001
  • Article

Review

Korean Journal of Biological Psychiatry 2001;8(1):111-5. Published online: Jan, 1, 2001

Abstract PDF Full Text

An Association Study of COMT Gene Polymorphism with Korean Alcoholism

  • Min-Jung Kim, PhD1;Byung-Hwan Yang, MD2;Jung-Sik Lee, MD3;Young-Gyu Chai, PhD4;and Taek-Kyu Park, PhD5;
    1;Department of Clinical Pathology, Hanyang University Hospital, Seoul, 2;Department of Neuropsychiatry, College of Medicine and The Medical Health Research Insititute, Hanyang University, Seoul, 3;Yong-In Mental Hospital, Yongin, Kyunggi-do, 4;Department of Biochemistry and Molecular Biology, Hanyang University, Ansan, 5;Department of Chemistry, College of Science, Kon-Kuk University, Seoul, Korea
Abstract

An association study with Korean alcoholic patients(n=50) and normal controls(n=53) was performed to find the relationship between catechol-O-methyltransferase(COMT) gene polymorphism and alcoholism using polymerase chain reaction-restriction fragment length polymorphism. When we compared the allele and genotype frequencies of Nla III COMT gene polymorphism in alcoholism and normal controls, there was no significant difference between two groups. Our results do not support an association between the Nla III polymorphism of COMT gene and alcoholism. 

Keywords Alcoholism;Association;COMT;Polymorphism.