Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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  • Korean Journal of Biological Psychiatry
  • Volume 8(1); 2001
  • Article

Review

Korean Journal of Biological Psychiatry 2001;8(1):116-22. Published online: Jan, 1, 2001

Abstract PDF Full Text

The Association between Polymorphism of the Dopamine D3 Receptors and Concentrations of Plasma Homovanillic and 5-hydroxyindoleacetic Acid, and Therapeutic Response of Chronic Schizophrenic Patients

  • Geo Jang Jeong, MD1;Min Soo Lee, MD, PhD1;Sang Yoon Kim1;Dae Yeop Kang, MD2;and Dong Il Kwak, MD, PhD1;
    1;Department of Psychiatry, College of Medicine, Korea University, Seoul, 2;Yong-In Mental Hospital, Kyunggi-do, Korea
Abstract

Objectives：Schizophrenia manifests a variety of interindividual differences in therapeutic response to antipsychotics. This might be attributable to dopamine and serotonin receptors that a important target for various antipsychotics, and the D3 receptor(DRD3) alleles they carry. The purpose of our study was to investigate whether the plasma levels of homovanillic acid(HVA) and 5-hydroxyindoleacetic acid(HIAA), and the polymorphism of DRD3 can be held as a predictor of treatment response in chronic schizophrenic patients. 

 Methods：Therapeutic response for 116 korean schizophrenia patient treated during 48 weeks were assessed by PANSS used as the clinical symptom rating scales. The levels of concentration of HVA and 5-HIAA were examined by HPLC at baseline and at 48 weeks. We classified the polymorphism of DRD3 receptor using amplifying by polymerase chain reaction(PCR). 

 Results：Neither concentrations of HVA and 5-HIAA nor genotype of dopamine 3 receptor were not significantly associated with the therapeutic response. But, the patients who has A1 alleles of DRD3 gene showed poor therapeutic responses.

 Conclusion：A1 allele of DRD3 gene is associated with poor prognosis of chronic schizophrenia.

Keywords Schizophrenia;Dopamine D3 receptor gene;Ser-9-Gly polymorphism;Homovanillic acid;5-Hydroxyindoleacetic acid.