Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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  • Korean Journal of Biological Psychiatry
  • Volume 8(2); 2001
  • Article

Review

Korean Journal of Biological Psychiatry 2001;8(2):251-7. Published online: Feb, 1, 2001

Abstract PDF Full Text

The Analysis of 40Hz Event-Related Potentials in Schizophrenia

  • Tak Youn, MD1,2;Hae-Jeong Park, PhD3;Do-Hyung Kang, MD1;Myung-Sun Kim, PhD4;Jae-Jin Kim, MD, PhD2; and Jun Soo Kwon, MD, PhD1,2,4;
    1;Department of Psychiatry, Seoul National University College of Medicine, Seoul, 2;BK21 Life Science, Seoul National University College of Medicine, Seoul, 3;Institute of Biomedical Engineering, Seoul National University College of Medicine, Seoul, 4;Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
Abstract

Backgrounds：Gamma band oscillatory activity is considered to be related to cognitive functions and illustrates that the concept of event-related oscillations bridges the gap between single neurons and neural assemblies. An event-related gamma oscillation is the time-locked responses of specific frequency, and can be identified by computing the amplitude frequency characteristics of the averaged event-related potentials(ERPs) after stimulation. 

 Objectives：We purposed to present experimental paradigm to investigate γ-band oscillation activities from the recording of ERPs by using auditory oddball paradigm and investigate the difference of γ-band activity between schizophrenia and normal controls. 

 Methods：The ERPs resulting from auditory stimuli with oddball paradigm in a group of schizophrenics(n=11), and also a group of age-, sex-, and handedness matched normal controls, were recorded by 128 channel EEG. The γ-band oscillatory activities were calculated by using time-frequency wavelet decomposition of the signal between 20 and 80Hz. The γ-band oscillatory activities of both groups were compared by t-test. 

 Results：The γ-band oscillatory of the leads Fz, Cz, and Pz of both groups were represented well in the time-frequency maps. Significant increases of the γ-band activity in normal controls compared with schizophrenics were observed around 160 msec, 350 msec, and 800 msec after stimulation.

 Conclusions：Our results suggested that the increment in γ-band oscillatory activity during cognitive operations and decreased γ-band activity in schizophrenics may be associated with the cognitive dysfunctions and the pathophysiology of the schizophrenia.

Keywords Gamma activity;Synchronization;40Hz;Auditory P300;Schizophrenia.