Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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  • Korean Journal of Biological Psychiatry
  • Volume 10(2); 2003
  • Article

Review

Korean Journal of Biological Psychiatry 2003;10(2):126-32. Published online: Feb, 1, 2003

Abstract PDF Full Text

The Effects of Venlafaxine on Neurite Growth of PC12 Cells

  • Hong-Seok Oh, MD1;Joon-Ho Choi, MD1;Jun-Seok Lee, MD, PhD2;Joon-Noh Lee, MD3;Mi-Ran Choi, MS4;Young-Gyu Chai, PhD4;Seok-Hyeon Kim, MD, PhD1; and Byung-Hwan Yang, MD, PhD1;
    1;Department of Neuropsychiatry, College of Medicine and Institute of Mental Health, Hanyang University, Seoul, 2;Department of Neuropsychiatry, College of Medicine, Kwandong University, Myongji Hospital, Goyang, 3;Department of Neuropsychiatry, College of Medicine, Hanyang University and Seoul National Hospital, Seoul, 4;Department of Biochemistry and Molecular biology, College of Science, Hanyang University, Ansan, Korea
Abstract

Objectives：The purpose of this study is to examine the effects of venlafaxine, one of novel antidepressant drugs, on neurite growth in PC12 cells.

Methods：PC12 cells were cultured with NGF for eight days. Then different concentrations(0μM, 1μM, 5μM) of venlafaxine were mixed with cultured PC12 cells. After 24 hours and 48 hours of culture, we compared the effects of venlafaxine on the total length of neurites of cultured PC12 cells between no venlafaxine treated group(0μM) and venlafaxine treated groups(1μM and 5μM). Additionally, we studied the concentration-dependent effect of venlafaxine on differentiation in PC12 cells.

Results：Experimental results showed that 1) the mean length of neurites in 1μM and 5μM venlafaxine treated group was more increased than no venlafaxine treated group(p=0.002). 2) the length of neurite in 5μM venlafaxine treated group was more elongated than 1μM venlafaxine treated group(p=0.046). 3) the length of neurite in 6μM venlafaxine treated group was more elongated than all the other concentrations in our experiment. Above 6μM, the length of neurite was shortened in inverse proportion to the concentration of venlafaxine.

Conclusions：This results suggest that venlafaxine, one of novel antidepressant drugs, promotes the differentiation of neuron. This study is believed to be a first step toward understanding the molecular and cellular mechanisms of antidepressant treatment.

Keywords Antidepressant;PC12 cell;Neurite growth;NGF.