Oct, 1, 2023

Vol.30 No.2, pp. 84-88

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  • Korean Journal of Biological Psychiatry
  • Volume 10(2); 2003
  • Article

Review

Korean Journal of Biological Psychiatry 2003;10(2):168-76. Published online: Feb, 1, 2003

Abstract PDF Full Text

The P300 Source Localization in the Patients with Obsessive-Compulsive Disorder using the LORETA Imaging and SPM

  • Sung-Kun Park, MD1;Jung-Seok Choi, MD1;Soh-Young Yu, MD1;Bo Reom Lee, MD2;Seung-Suk Kang, MD2;Kyu Sik Roh, MD1;Tae-Hyun Ha, MD1;Jun Soo Kwon, MD, PhD1;
    1;Department of Psychiatry, Seoul National University College of Medicine, Seoul, 2;Clinical Research Institute, Seoul National University Hospital, College of Medicine, Seoul. Korea
Abstract

Objectives：We investigated the characteristics of P300 generators in obsessive-compulsive disorder(OCD) patients by using voxel-based statistical parametric mapping of current density images.

Methods：P300 generators, produced by a rare target tone of 1500Hz under a frequent non-target tone of 1,000Hz, were measured in 15 right-handed OCD patients and 15 controls. Low Resolution Electromagnetic Tomography(LORETA), using a realistic head model of the boundary element method based on individual MRI, was applied to the 128-channel EEG. Statistical parametric mapping(SPM) was applied for the statistical analysis.

Results：We found that both groups had the mean current density of P300 in the parietal, temporal and prefrontal lobe. There was a trend for decreased current density in the prefrontal area in OCD patients. The statistical comparison showed current density increase in the supraparietal area, a statistically significant longer P300 latency and a trend for reduced P300 amplitude in OCD patients.

Conclusion：It suggests that P300 source of both groups exists in multiple brain regions at the same time. And both groups had no statistically significant differences in the current density of P300 except for increased current density in the supraparietal area in OCD patients. But, considering the statistically significant longer P300 latency, a trend for reduced P300 amplitude and relative mean current density reduction in the prefrontal area in OCD patients, this study suggests that the frontal lobe may have a reduced normal inhibitory process in OCD patients.

Keywords Obsessive-compulsive disorder;P300;Source localization;LORETA;SPM.